Tango Therapeutics 100 Binney Street, Suite 700 Cambridge, MA 02142 Tel: +1-857-320-4900. Glassdoor gives you an inside look at what it's like to work at HotSpot Therapeutics, including salaries, reviews, office photos, and more. Maintain Homeostasis. BOSTON, Jan. 10, 2022 /PRNewswire/ -- HotSpot Therapeutics, Inc., a biotechnology company pioneering the discovery and development of first- and best-in-class allosteric therapies targeting . We're a tight-knit team of proven drug hunters, deep learning researchers, and software engineers collaborating to drive AI in biochemistry, discovering and developing new therapies for patients suffering from severe disorders. XTX301 is an engineered form of IL-12 that is masked with a protein domain to prevent binding activity until cleaved off by TME-associated proteases. Learn More About Our Approach. Learn More about our PIPE-791 Program. Email: info@centrexion.com Phone: (617) 837-6911 . Connect with us on Linkedin; HotSpot Therapeutics, Inc., a biotechnology company pioneering the discovery and development of first-in-class allosteric therapies targeting regulatory sites on proteins referred to as "natural hotspots," today announced the close of its oversubscribed $100 million Series C financing, bringing its total funding to $190 million. TScan Therapeutics Announces Presentation at the 11th Annual SVB Leerink Global Healthcare Conference. Free interview details posted anonymously by HotSpot Therapeutics interview candidates. Vividion Therapeutics is removing the boundaries of druggability to develop therapies for patients with critical unmet needs across multiple therapeutic areas. You can compare up to 12 companies. Quell Therapeutics is a London, UK based, private biopharmaceutical company. Sonoma Biotherapeutics Expands Leadership Team with the Appointment of Doug Sheehy, J.D., as Chief Legal Officer and Secretary. See company Profile. About Us. For example, a human's internal temperature is approximately 37 . Otsuka and Click Therapeutics Initiate First-of-its-Kind Fully Remote Clinical Trial Using Digital Therapeutics as Adjunctive Therapy in Adults With Major Depressive Disorder read more. Kymera Therapeutics is a clinical stage biopharmaceutical company pioneering a transformative new modality, "targeted protein degradation" (TPD), with the ability to pursue targets long considered undruggable and to treat disease in entirely new ways. HotSpot Therapeutics. Siduma's culture is centered on science and supported by our core principles: trust, courage, humility, collaboration . Sonoma Biotherapeutics Raises $265 Million in an Oversubscribed Series B Financing to Translate the Promise of Cell Therapy into Curative Medicines for Autoimmune and Other . HotSpot Therapeutics, Inc., a biotechnology company pioneering the discovery and development of first- and best-in-class allosteric therapies targeting regulatory sites on proteins referred to as "natural hotspots," today announced it will present additional pre-clinical data on the company's CBL-B program in a poster presentation at the American Association for Cancer Research (AACR) Annual . BOSTON, March 8, 2022 /PRNewswire/ -- HotSpot Therapeutics, Inc., a biotechnology company pioneering the discovery and development of first- and b. HotSpot Therapeutics, Inc., a biotechnology company pioneering the discovery and development of first- and best-in-class allosteric therapies targeting regulatory sites on proteins referred to as . Carisma offers the chance to make a direct impact on cancer and other diseases through exciting novel technologies. Powered by our proprietary REMaster technology platform, we can now create medicines with the unique ability to alter the way genes are read from the genome, correcting dysregulation or eliminating the . Our unique therapeutic approach bypasses the need for ex vivo cell manipulations and the . We have assembled a world-class team, including some of the foremost scientific leaders in the fields of oncology and adoptive cell therapy (ACT). . HotSpot Therapeutics Logo (PRNewsfoto/HotSpot Therapeutics) CBL-B acts as a gatekeeper in immune cell activation, and its inhibition holds the potential to address several key mechanisms where . Shield Therapeutics is a well-funded, high potential, commercial stage specialty-pharma company. I'm proud to be a part of such a dedicated team of scientists . Tumor cell clearance reimagined. $103K-$209K Per Year (Glassdoor est.) Boston, MA 30d+. News. Image: Paweł Czerwiński / Unsplash / CC BY SA ‑ Creative Commons Attribution + ShareAlike. Preclinical PoC for both NLRP3 and STING agonists demonstrated. The Company is evaluating RSLV-132 in . Its mission is to discover, develop and commercialize novel and transformative therapies . 3 HotSpot Therapeutics reviews. BMS dosed initial patient with first-in-class NLRP3 agonist, IFM-1222 . HotSpot Therapeutics to Present at the BMO Biopharma Spotlight Series. Maze Therapeutics: translating genetic insights into therapeutic innovations. With our robust and innovative discovery engine, we strike cancer at its core by engineering cell therapies that target Neoantigens (neoAg) arising from genomic mutations. Learn More about our PIPE-307 Program. HotSpot Therapeutics is targeting naturally occurring pockets on proteins called "natural hotspots" that are decisive in the control of cellular protein function. Press release content from PR Newswire. Treating multiple sclerosis and other demyelinated diseases by creating a portfolio of first-in-class small molecules to initiate axonal myelin restoration, or remyelination. Our Strategy. harnessing the potential of modern human genetics to treat disease. Lengo Therapeutics Logo CAMBRIDGE, Mass. Caris Life Sciences®(Caris), the leading molecular science and technology company actively developing and delivering innovative solutions to revolutionize healthcare, and HotSpot Therapeutics . Xealth's top competitors include Precision BioSciences, Olio, AmacaThera and HotSpot Therapeutics. Smart Allostery™ HotSpot Therapeutics' platform - Smart Allostery™ - is the first that integrates machine learning, structure-function and tailored chemistry to systematically uncover and drug pockets on proteins used to control their function. Our Science. 1 HotSpot Therapeutics Strategy Analyst interview questions and 1 interview reviews. 2017. SEPTEMBER. Healthcare Providers It's an exciting time in neuroscience. We are committed to delivering solutions for patients who may have once thought there was no treatment option for their disease. Building on seminal work of its scientific founders, Mozart Therapeutics is capitalizing on a novel CD8 T regulatory cell network to develop innovative disease-modifying therapies for autoimmune and inflammatory diseases. Precision BioSciences is a genome editing company dedicated to . HOUSTON, May 02, 2022 (GLOBE NEWSWIRE) -- Alaunos Therapeutics, Inc. ("Alaunos" or the "Company") (Nasdaq: TCRT), a clinical-stage oncology-focused cell therapy company today announced a poster presentation highlighting the Company's membrane-bound interleukin-15 (mbIL-15) program as a potentially potent cell therapy targeting hotspot . BOSTON, April 8, 2022 /PRNewswire/ -- HotSpot Therapeutics, Inc., a biotechnology company pioneering the discovery and development of first- and best-in-class small molecule allosteric therapies . We pride ourselves on providing solutions to unmet medical needs and delivering value to our shareholders. 3D spatial graph modeling + cutting-edge molecular simulation to generate novel drug candidates. Boston, MA 30d+. A unified team with a singular mission. CERs explained. Kymera is . By identifying and optimizing allosteric binding sites that have never before been targeted, Gain is unlocking new treatment options for difficult-to-treat disorders characterized by protein misfolding, including lysosomal storage disorders. All content is posted anonymously by employees working at HotSpot Therapeutics. Add company. Show Salary Details. PMID: 23371856; PMCID: PMC3714231. We also believe that more precisely targeted therapeutics could better address the cause of a patient's disease. Together, they have architected a new and innovative approach to target and drug discovery. Save Job. Work alongside world renowned scientist Dr. Craig Crews and a fearless team of innovators who envision bold new ways to unburden the treatment of serious diseases. Sr. HotSpot Therapeutics. Nimbus Therapeutics is backed by world-class life science investors, including those listed below and others. Geraldine Harriman, Ph.D., is Co-Founder and Chief Scientific Officer at HotSpot Therapeutics, a biotechnology company developing first-in-class allosteric therapies by applying HotSpot's Smart Allostery platform. At the heart of Harpoon's approach is a novel antibody-derived platform called TriTAC ® (Tri-specific T cell Activating Construct . By identifying and optimizing allosteric binding sites that have never before been targeted, Gain is unlocking new treatment options for difficult-to-treat disorders characterized by protein misfolding, including lysosomal storage disorders. Brand New . We are applying Gen . Functions Performed. HotSpot Therapeutics, Inc., a biotechnology company pioneering the discovery and development of first- and best-in-class allosteric therapies targeting regulatory sites on proteins referred to as "natural hotspots," today announced it will present additional pre-clinical data on the company's CBL-B program in a poster presentation at the American Association for Cancer Research (AACR) Annual . The company closed a $24 million Series A financing in June 2011, a $43 million Series B financing in March 2015, an additional $65 million in financing in June 2018, $60 million in financing in October 2020, and $105 million in financing in July 2021. Jubilant Therapeutics is a patient-centric biopharmaceutical company advancing potent and selective small molecule modulators to address significant unmet medical needs in oncology and autoimmune diseases. Resolve Therapeutics is pioneering first-in-class compounds for Systemic Lupus Erythematosus (SLE; "lupus") and primary Sjögren's syndrome (pSS). $77K-$134K Per Year (Glassdoor est.) Research Scientist salaries at HotSpot Therapeutics can range from $10,232-$11,095. Investors. Before joining Johnson & Johnson, David held leadership positions at Allergan, Inc., for 25 years where he served primarily in the sales and marketing areas in . Prior to joining Nightstar Therapeutics, he was the Vice President of Johnson & Johnson's Vision Care Franchise where he led the global marketing, new product and licensing activities. We are genetic navigators, charting the complex maze of human genetics to create precision medicines to fight disease and help patients in need. Maintain Homeostasis. the maze approach. and SAN DIEGO, Nov. 29, 2021 /PRNewswire/ -- Blueprint Medicines Corporation (NASDAQ: . Kymera is a clinical stage biopharmaceutical company developing novel protein degrader therapeutics to treat disease in powerful new ways, which harness the body's natural protein degradation system to selectively degrade disease causing proteins with the goal of completely removing them from the body. Contact; Careers . When a living system is in homeostasis, it means that internal conditions are stable and relatively constant. HotSpot Therapeutics. Stay Connected. BOSTON, May 21, 2020 /PRNewswire/ -- HotSpot Therapeutics, Inc, a biotechnology company pioneering the discovery and development of first-in-class allosteric therapies targeting nature's . Please remove a company to add a new one. David Diller Director of Comp Chem at HotSpot Therapeutics, Inc. Hightstown, New Jersey, United States 500+ connections IFM Therapeutics's $27M Series A closed. We are sharply focused on dry AMD which is a disease comprised of numerous genetic variants. November 16, 2021. This is the HotSpot Therapeutics company profile. European Investment Bank provides Minoryx with up to €25 million to support development of breakthrough therapies in orphan neurodegenerative . We are designing the next generation of immunotherapeutic antibodies for the treatment of cancer, infectious disease, and autoimmune disease. For example, a human's internal temperature is approximately 37 . . SEPTEMBER. Gain Therapeutics is redefining drug discovery with its SEE-Tx™ target identification platform. TScan Therapeutics Announces Upcoming Presentations at the 25th American Society of Gene and Cell Therapy Annual Meeting. We are focused on improving the lives of patients with genetically defined diseases in areas of high unmet medical need. Our mission is to discover, translate, and deliver pioneering curative cell therapies that incorporate multiple forms of tumor clearance into single T cells. HotSpot Therapeutics Logo. Mission Therapeutics is determined to make a positive impact on the lives of patients suffering from serious diseases including acute kidney injury (AKI), rare mitochondria diseases, neurodegeneration, and fibrosis by developing first-in-class therapeutics that inhibit disease-associated deubiquitylating enzymes (DUBs). Alaunos is a clinical stage cellular immuno-oncology company dedicated to the treatment of solid tumors through adoptive TCR-T cell therapy. Director of Structure Biology and Protein Science. The AP news staff was not involved in its creation. Our Science. At AVROBIO, we aim to halt or reverse disease with a single dose of gene therapy. A message on the evolution of cancer treatment, Lyell's commitment to scientific innovation, and how we are working toward our goal of curative cell therapy for any solid tumor. Explore section $2.32B sale of IFM Uno to BMS closed; IFM Therapeutics, LLC created as a spin-out, and IFM Tre launched. Immerse yourself in a collaborative and courageous culture. TScan Therapeutics Appoints Leiden Dworak, CPA, MBA, as Vice President, Finance. Led by Pivotal bioVenture Partners, with significant participation by LSP and B Capital Group, the round includes new investors Monashee Investment Management, LLC, CaaS . 2017. HotSpot Therapeutics is targeting naturally occurring pockets on proteins called "natural hotspots" that are decisive in the control of cellular protein function. Harpoon is a clinical-stage immuno-oncology company developing a novel class of T cell engagers that unleash the natural power of the T cells to fight cancer and other diseases. 2.2 The trademarks, service marks, and logos owned by HotSpot that are used and displayed on this Website, including, without limitation, all such . competitors. Functions Performed. Hear from some of our team members about what drives them to help ensure patients live their best lives. Our advancing pipeline of first-in-class 'CD8 Treg cell modulators' are designed to restore durable immune . HotSpot Therapeutics. 2018. ABOUT Us. Dramatic advances in human genetics . HotSpot Therapeutics, Inc., a biotechnology company pioneering the discovery and development of first- and best-in-class allosteric therapies targeting regulatory sites on proteins referred to as . Spearheading Immunotherapies. Carisma Therapeutics does meaningful work on a daily basis. Click Therapeutics Secures $30M in Growth Capital from K2 HealthVentures to Expand Operations Our lead product candidate, RSLV-132, has the potential to prevent the inflammation that causes the debilitating symptoms of autoimmune diseases. 2017. Our lead programs are initially focused on treating hematologic malignancies by leveraging the Interius platform to generate chimeric antigen receptor (CAR) T cells directly in vivo. At Sage, our goal is to originate meaningfully differentiated drug candidates. This estimate is based upon 1 HotSpot Therapeutics Research Scientist salary report (s) provided by employees or estimated based upon statistical methods. Largely unexploited by industry . Welcome to Quell. It… Liked by Patrick DePaolo, Ph.D See all Research Scientist salaries to learn how this stacks up in the market. September 16, 2021. ImCheck Therapeutics is driving innovation in immune system modulation based on our unique know-how in the butyrophilin (BTN) and BTN-like (BTNL) superfamily of checkpoint molecules. A free inside look at company reviews and salaries posted anonymously by employees. Minoryx Therapeutics and Sperogenix Therapeutics enter into an exclusive license agreement to develop and commercialize leriglitazone in mainland China, Hong Kong and Macau. When a living system is in homeostasis, it means that internal conditions are stable and relatively constant. Gain Therapeutics is redefining drug discovery with its SEE-Tx™ target identification platform. Press 2020-12-01. Core Technologies Enable In Situ Re‑engineering of Cellular Functions. The HotSpot team was thrilled to present pre-clinical data for our CBL-B program supporting the role of CBL-B inhibition at #AACR22 this weekend. The majority of advances in immunotherapy have focused on targeting the adaptive immune . Gemini Therapeutics is a precision medicine company focused on the development of new therapies through a deeper understanding of disease. NEW WAY TO WATCH! HotSpot is industrializing the discovery of allosteric medicines, targeting natural hotspots to treat diseases in new ways. Free interview details posted anonymously by HotSpot Therapeutics interview candidates. Targeted Protein Degradation. Our goal is simple and powerful: We aim to enable individuals with genetic disease to live longer — free from disease progression, free from painful and debilitating symptoms and free from the burden of chronic treatment regimens. 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